Globalization involves structural changes in forms of state, society and culture, ecology and political economy and in ethics and expectations. In this IPE Classic, with a new Foreword and Preface, globalization and multilateralism are linked to questions of epistemology, ontology, and strategy. Epistemology entails critical questioning of the nature of knowledge and its foundations. Ontology concerns the significant factors in global political economy. Strategy involves how to move world affairs from its present condition towards normative goals enunciated in the MUNS programme, so as to promote collective ability to channel structural change in a more democratic direction.