The tremendous success of the so-called metathesis reaction during the last decade (Nobel prize 2005) is reflected in its huge impact on natural product synthesis and related fields. A very significant portion of contemporary total syntheses comprises at least one metathetic conversion; while many of them rely on metathesis as the key strategic element. Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications. From the contents: â? Synthesis of natural products containing medium-size carbocycles, macrocycles, oxygen and nitrogen heterocycles by ring-closing alkene metathesis â? Phosphorus and sulfur heterocycles â? Tethered ring-closing metathesis â? Metathesis involving a relay and applications in natural products synthesis â? Ene-yne metathesis â? Ring-closing alkyne metathesis â? Cross, cascade and asymmetric metathesis â? Solid-phase metathesis reactions Written by top international authors, this is a real must-have for anyone working in natural product synthesis.