The Second Edition of "Pathophysiology" offers a unique clinical approach that facilitates learning by viewing pathophysiology as health care professionals do. Whereas a traditional systems-based approach impractically isolates diseases to a single body system, this textbook's approach recognizes how disease affects multiple systems. Additionally, rather than covering only a limited number of diseases, aiming for rote memorization of the key factors in those diseases, the clinical approach details the mechanisms of disease. By mastering the core concepts of altered human function, students can apply a deeper understanding to a host of diseases, rather than trying to memorize facts about specific conditions. Because students learn through application, they learn to think about pathophysiology the way they will need to in a clinical setting, by working from symptoms to the cause, rather than the other way around. Each chapter discusses clinical models, enhancing the real-world application of the material.