Pharmacology's successful approach emphasises the mechanisms by which drugs act and relates these to the overall pharmacological effects and clinical uses. In doing so it sets out for the reader a clear route from a molecular understanding of receptors and drug actions, to the therapeutic uses of the most important groups of drugs. An especially well written textbook - it is regularly cited by students as the best textbook they have used. Presented in full colour, with a new page format and design, the Fifth Edition has been fully updated, incorporating significant new information published in the last few years while dated or obsolete material has been removed. New agents are fully discussed as well as extensions of basic knowledge which presage further drug development.