The liver is an amazing organ which performs a myriad of functions necessary for life. The regenerative capacity of the liver is captivating and has been recognized for centuries. However, when the liver is overwhelmed by insulting stimuli or is chronically damaged, the regenerative capability of the liver is substantially reduced or lost. Therefore researchers have been working together to find solutions to cure failing human liver function. Given the ability of stem cells to self renew and differentiate into specialized cell liver types they represent an attractive strategy to replace lost liver function and it was felt that a book collating recent research in this field should be written. The book begins by outlining the complex nature of human liver disease and examine the potential that stem cell based approaches have to offer.