Thoroughly revised and updated for its Sixth Edition with the help of the physician educators of Doctors in Training.com, LLC, Step-Up to USMLE Step 1 is the most effective, comprehensive, systems-based review for the USMLE Step 1 exam. The book has been widely acclaimed for its high-yield, systems-based organization, which parallels the USMLE Step 1 content outline and helps students synthesize the information from their basic science courses. The popular, user-friendly format features numerous charts and diagrams and "Quick Hits" notes in the margins that help students integrate concepts across systems. The Sixth Edition has been updated to include more in-depth Biochemistry and Microbiology content, giving each subject its own dedicated chapter. In addition, the 2014 edition continues to offer clinical vignettes in each chapter; pharmacology, integrated into the systems-based format; and the popular "Crunch Time Review" section. It is a companion Website that features a sample question bank.